Rewcastle, Gordon W.: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

Rewcastle, Gordon W., Denny, William A., Bridges, Alexander J., Zhou, Hairong, Cody, Donna R., McMichael, Amy, Fry, David W.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 756 KB

english, 1995

2

Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4- d ]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors

Rewcastle, Gordon W., Murray, Donna K., Elliott, William L., Fry, David W., Howard, Curtis T., Nelson, James M., Roberts, Billy J., Vincent, Patrick W., Hollis Showalter, H. D., Winters, R. Thomas, De

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 135 KB

english, 1998

3

Design and synthesis of novel fluorinated surfactants for hydrocarbon subphases

Katritzky, Alan R., Davis, Terry L., Rewcastle, Gordon W., Rubel, Glenn O., Pike, Mike T.

Journal:

Year:

1988

Language:

english

File:

PDF, 502 KB

english, 1988

4

Functional differences between two classes of oncogenic mutation in the PIK3CA gene

Claire Chaussade, Kitty Cho, Claire Mawson, Gordon W. Rewcastle, Peter R. Shepherd

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 350 KB

english, 2009

5

[Advances in Heterocyclic Chemistry] Advances in Heterocyclic Chemistry Volume 56 Volume 56 || Generation and Reactions of sp2-Carbanionic Centers in the Vicinity of Heterocyclic Nitrogen Atoms

Rewcastle, Gordon W.

Year:

1993

Language:

english

File:

PDF, 6.24 MB

english, 1993

6

Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2'-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide)

Rewcastle, Gordon W., Palmer, Brian D., Dobrusin, Ellen M., Fry, David W., Kraker, Alan J., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.35 MB

english, 1994

7

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

Rewcastle, Gordon W., Gamage, Swarna A., Flanagan, Jack U., Kendall, Jackie D., Denny, William A., Baguley, Bruce C., Buchanan, Christina M., Chao, Mindy, Kestell, Philip, Kolekar, Sharada, Lee, Woo-J

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

8

Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

Rewcastle, Gordon W., Gamage, Swarna A., Flanagan, Jack U., Frederick, Raphael, Denny, William A., Baguley, Bruce C., Kestell, Philip, Singh, Ripudaman, Kendall, Jackie D., Marshall, Elaine S.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.06 MB

english, 2011

9

STRUCTURE-ACTIVITY RELATIONSHIPS FOR 4-ANILINOQUINAZOLINES AS POTENT INHIBITORS AT THE ATP BINDING SITE OF THE EPIDERMAL GROWTH FACTOR RECEPTOR IN VITRO

William A Denny, Gordon W Rewcastle, Alexander J Bridges, David W Fry, Alan J Kraker

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

1996

Language:

english

File:

PDF, 345 KB

english, 1996

10

Potential antitumor agents. 48. 3'-Dimethylamino derivatives of amsacrine: redox chemistry and in vivo solid tumor activity

Atwell, Graham J., Rewcastle, Gordon W., Baguley, Bruce C., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 991 KB

english, 1987

11

Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1 H )-ones as Selective Inhibitors of pp60 c - src

Thompson, Andrew M., Rewcastle, Gordon W., Boushelle, Stacey L., Hartl, Brian G., Kraker, Alan J., Lu, Gina H., Batley, Brian L., Panek, Robert L., Showalter, H. D. Hollis, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 255 KB

english, 2000

12

Evidence for a role for the p110-α isoform of PI3K in skeletal function

Andrew Grey, Claire Chaussade, Victoria Empson, Jian-Ming Lin, Maureen Watson, Susannah O’Sullivan, Gordon Rewcastle, Dorit Naot, Jillian Cornish, Peter Shepherd

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 837 KB

english, 2010

13

Potential antitumor agents. 47. 3'-Methylamino analogs of amsacrine with in vivo solid tumor activity

Atwell, Graham J., Baguley, Bruce C., Finlay, Graeme J., Rewcastle, Gordon W., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1.08 MB

english, 1986

14

Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells

Euphemia Leung, Gordon W. Rewcastle, Wayne R. Joseph, Rhonda J. Rosengren, Lesley Larsen, Bruce C. Baguley

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 687 KB

english, 2012

15

Directed Synthesis of 1-Substituted Phenoxazines

R. Katritzky, Alan, M. Vazquez de Miguel, Luis, W. Rewcastle, Gordon

Journal:

Year:

1987

Language:

english

File:

PDF, 126 KB

english, 1987

16

Unequivocal Synthesis of Phenazine-1-Carboxylic Acids: Selective Displacement of Fluorine During Alkaline Borohydride Reduction of N-(2-Fluorophenyl)-3-Nitroanthranilic Acids

Rewcastle, Gordon W., Denny, William A.

Journal:

Synthetic Communications

Year:

1987

Language:

english

File:

PDF, 282 KB

english, 1987

17

Structure-activity relationships for the mutagenic activity of tricyclic intercalating agents in Salmonella typhimurium

William A. Denny, Pamela M. Turner, Graham J. Atwell, Gordon W. Rewcastle, Lynnette R. Ferguson

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1990

Language:

english

File:

PDF, 623 KB

english, 1990

18

Potential antitumor agents. 41. Analogs of amsacrine with electron-donor substituents in the anilino ring

Atwell, Graham J., Rewcastle, Gordon W., Denny, William A., Cain, Bruce F., Baguley, Bruce C.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 836 KB

english, 1984

19

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors

Jackie D. Kendall, Gordon W. Rewcastle, Raphael Frederick, Claire Mawson, William A. Denny, Elaine S. Marshall, Bruce C. Baguley, Claire Chaussade, Shaun P. Jackson, Peter R. Shepherd

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 614 KB

english, 2007

20

Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit

Philip Kestell, James W. Paxton, Gordon W. Rewcastle, Ingrid Dunlop, Bruce C. Baguley

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 193 KB

english, 1999

21

Potential antitumor agents. 49. 5-Substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity

Denny, William A., Atwell, Graham J., Rewcastle, Gordon W., Baguley, Bruce C.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 868 KB

english, 1987

22

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Smaill, Jeff B., Rewcastle, Gordon W., Loo, Joseph A., Greis, Kenneth D., Chan, O. Helen, Reyner, Eric L., Lipka, Elke, Showalter, H. D. Hollis, Vincent, Patrick W., Elliott, William L., Denny, Willia

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 286 KB

english, 2000

23

Potential antitumor agents. 51. Synthesis and antitumor activity of substituted phenazine-1-carboxamides

Rewcastle, Gordon W., Denny, William A., Baguley, Bruce C.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.27 MB

english, 1987

24

DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular

Buchanan, Christina M., Shih, Jen‑Hsing, Astin, Jonathan W., Rewcastle, Gordon W., Flanagan, Jack U., Crosier, Philip S., Shepherd, Peter R.

Journal:

Clinical Science

Year:

2012

Language:

english

File:

PDF, 544 KB

english, 2012

25

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

Lancaster, Graeme I., Skiba, Beata, Yang, Christine, Nicholls, Hayley T., Langley, Katherine G., Chan, M. H. Stanley, Bruce, Clinton R., Rewcastle, Gordon W., Shepherd, Peter R., Karin, Michael, Febbr

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

26

The Synthesis of Substituted 9-Oxoacridan-4-carboxylic Acids; Part 2. The Use of 2-lodoisophthalic Acid in the Jourdan-Ullmann Reaction

Rewcastle, Gordon W., Denny, William A.

Journal:

Year:

1985

File:

PDF, 271 KB

1985

27

Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids

Rewcastle, Gordon W., Atwell, Graham J., Zhuang, Li, Baguley, Bruce C., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 830 KB

english, 1991

28

Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Dithiobis(1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor Protein Tyrosine Kinases

Palmer, Brian D., Rewcastle, Gordon W., Thompson, Andrew M., Boyd, Maruta, Showalter, H. D. Hollis, Sercel, Anthony D., Fry, David W., Kraker, Alan J., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 2.14 MB

english, 1995

29

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions.

Smaill, Jeff B., Rewcastle, Gordon W., Bridges, Alexander J., Zhou, Hairong, Showalter, H. D. Hollis, Fry, David W., Nelson, James M., Sherwood, Veronika, Elliott, William L., Vincent, Patrick W., DeJ

Journal:

Journal of Medicinal Chemistry

Year:

2000

File:

PDF, 7 KB

2000

30

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Spicer, Julie A., Rewcastle, Gordon W., Kaufman, Michael D., Black, Shannon L., Plummer, Mark S., Denny, William A., Quin, John, Shahripour, Aurash B., Barrett, Stephen D., Whitehead, Christopher E.,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 488 KB

english, 2007

31

Potentiation of Growth Inhibitory Responses of the mTOR Inhibitor Everolimus by Dual mTORC1/2 Inhibitors in Cultured Breast Cancer Cell Lines

Leung, Euphemia Y., Askarian-Amiri, Marjan, Finlay, Graeme J., Rewcastle, Gordon W., Baguley, Bruce C., Ho, Yuan-Soon

Journal:

Year:

2015

Language:

english

File:

PDF, 1.97 MB

english, 2015

32

Phenazine-1-carboxamides: Structure–cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain

Swarna A. Gamage, Gordon W. Rewcastle, Bruce C. Baguley, Peter A. Charlton, William A. Denny

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 198 KB

english, 2006

33

Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives

Rewcastle, Gordon W., Denny, William A., Winters, R. Thomas, Colbry, Norman L., Showalter, H. D. Hollis

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 872 KB

english, 1996

34

Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

Atwell, Graham J., Rewcastle, Gordon W., Baguley, Bruce C., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 812 KB

english, 1987

35

Chronic Benign Congenital Myopathy: Fingerprint Body Type

Gordon, A.S., Rewcastle, N.B., Humphrey, J.G., Stewart, B.M.

Journal:

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Year:

1974

Language:

english

File:

PDF, 10.28 MB

english, 1974

36

Biochemical and antiproliferative properties of 4-[Ar(alk)ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor

David W Fry, James M Nelson, Veronika Slintak, Paul R Keller, Gordon W Rewcastle, William A Denny, Hairong Zhou, Alexander J Bridges

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.24 MB

english, 1997

37

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Chaussade, Claire, Rewcastle, Gordon W., Kendall, Jackie D., Denny, William A., Cho, Kitty, Grønning, Line M., Chong, Mei Ling, Anagnostou, Sasha H., Jackson, Shaun P., Daniele, Nathalie, Shepherd, Pe

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 608 KB

english, 2007

38

Combining properties of different classes of PI3Kα inhibitors to understand molecular features that confer selectivity.

Gong, Grace Q, Kendall, Jackie D, Dickson, James MJ, Rewcastle, Gordon W, Buchanan, Christina M, Denny, William A, Shepherd, Peter R, Flanagan, Jack U.

Journal:

Biochemical Journal

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

39

Structure–activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1

Brian D. Palmer, Jeff B. Smaill, Gordon W. Rewcastle, Ellen M. Dobrusin, Alan Kraker, Charles W. Moore, Randall W. Steinkampf, William A. Denny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 138 KB

english, 2005

40

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

Sweetlove, Melanie, Wrightson, Emma, Kolekar, Sharada, Rewcastle, Gordon W., Baguley, Bruce C., Shepherd, Peter R., Jamieson, Stephen M. F.

Journal:

Frontiers in Oncology

Year:

2015

Language:

english

File:

PDF, 16.13 MB

english, 2015

41

The New Zealand Institute of Chemistry

Gordon Rewcastle

Journal:

Chemistry – An Asian Journal

Year:

2011

Language:

english

File:

PDF, 447 KB

english, 2011

42

Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength

Smith, Greg C., Ong, Wee-Kiat, Costa, Jessica L., Watson, Maureen, Cornish, Jillian, Grey, Andrew, Gamble, Greg D., Dickinson, Michelle, Leung, Sophie, Rewcastle, Gordon W., Han, Weiping, Shepherd, Pe

Journal:

Year:

2013

Language:

english

File:

PDF, 778 KB

english, 2013

43

Dienone?phenol type rearrangements. Part 5. Confirmation of a rearrangement pathway using carbon-13 labelling

Davis, Brian R., Rewcastle, Gordon W., Woodgate, Paul D.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1978

Language:

english

File:

PDF, 465 KB

english, 1978

44

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Smith, Greg C., Ong, Wee Kiat, Rewcastle, Gordon W., Kendall, Jackie D., Han, Weiping, Shepherd, Peter R.

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

45

Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells

Leung, Euphemia, Kim, Ji Eun, Rewcastle, Gordon W., Finlay, Graeme J., Baguley, Bruce C.

Journal:

Cancer Biology & Therapy

Year:

2011

Language:

english

File:

PDF, 3.78 MB

english, 2011

46

Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine

Rewcastle, Gordon W., Atwell, Graham J., Baguley, Bruce C., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 533 KB

english, 1984

47

Potential antitumor agents. 37. Organophosphorus derivatives of 9-anilinoacridine

Rewcastle, Gordon W., Baguley, Bruce C., Cain, Bruce F.

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 656 KB

english, 1982

48

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Rewcastle, Gordon W., Palmer, Brian D., Bridges, Alexander J., Showalter, H. D. Hollis, Sun, Li, Nelson, James, McMichael, Amy, Kraker, Alan J., Fry, David W., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 398 KB

english, 1996

49

Heterocyclic carbanions. Synthesis of 2-substituted imidazole and benzimidazoles and of 3-substituted pyrazoles by lithiation of N-(dialkylamino)methyl heterocycles

Katritzky, A. R., Rewcastle, Gordon W., Fan, Wei Qiang

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 705 KB

english, 1988

50

Palladium-Catalyzed Cross-Coupling in the Synthesis of Pyridinyl Boxazomycin C Analogues

Richardson, Chris, Rewcastle, Gordon W., Hoyer, Denton, Denny, William A.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 87 KB

english, 2005

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски